Incidence of neural tube defects in the least-developed area of India: a population-based study.
نویسندگان
چکیده
Hospital-based records from major cities of India, where roughly a quarter of the population resides, identified the frequency of neural tube defects (NTDs) as ranging from 3.9 to 8.8 per 1000 births, but the incidence in rural areas is unknown. We did a population-based door-to-door survey of mothers living in remote clusters of villages in Balrampur District in Uttar Pradesh, a region ranked as the least-developed area in India. The data showed that the incidence of NTDs was 6.57-8.21 per 1000 livebirths, which is among the highest worldwide. India's Ministry of Health needs to produce a strategy to reduce the incidence of such defects.
منابع مشابه
Effect of arsenic on neural tube in mouse embryo and relation to reduced folate carrier (RFC-1)
Arsenic is an important environmental toxicant which is usually found in drinking water in inorganic form. The hypothesis tested in this investigation is; arsenic exposure causes neural tube defects (NTDs) andthese defects of the central nervous system are more likely related to folate deficiency during fetal life. In this study, sodium arsenate was administered via intraperitoneal route at a r...
متن کاملNEURAL TUBE DEFECTS IN NEWBORNS IN THE SOUTH-EAST OF THE CASPIAN SEA BORDER (GORGAN, IRAN 1998-2000)
Neural tube defects (NTD) are one of the most important malformations of newborns. The aim of this research is to determine the rates of NTD, anencephaly and spina bifida cystica and the relations of these abnormalities to the factors including sex, race, ethnicity, maternal age and familial marriage in the south-east of the Caspian Sea border. A three-year descriptive-analytic and cross-s...
متن کاملاثرات تراتوژنیک گاباپنتین بر تکامل لوله عصبی و اسکلتی جنین های موش سوری
Background and purpose : Gabapentin is a new Antiepileptic drugs that introduced for the treatment of partial and second generalized seizures. Other usages of this drug include relief of neuropathic pains such as diabetic and cancers neuropathy and also prophylaxy of migrane. There is little information about the teratogenic effects of this drug. Only few studies reported delay in ossificatio...
متن کاملاثرات تراتوژنیک فنیتوئین برتکوین لوله عصبی و اسکلتیجنینهای موش سوری
Abstract Background: Phenytoin is one of the oldest anti epileptic drugs it may result in fetal abnormalities if taken during pregnancy. This study was designed to determine teratogenic effects of phenytoin on the development of skeleton and neural tube defects in mouse fetuses.. Materials and methods: Forty small experimental pregnant mice (NMRI Type) were divided in to three experimental...
متن کاملHYPERVITAMINOSIS A-INDUCED CENTRAL NERVOUS SYSTEM DEFECTS
In this investigation the effects of excess vitamin A administration during the early embryonic period were studied. Intramuscular injection of a single dose of 15000,20000 or 25000 IU/kg vitamin A to pregnant Balb/c strain mice on either day 7,8,9 or 10 of gestation (vaginal plug= day 0 of gestation) produced major malformations in the central nervous system (CNS) including exencephaly, h...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Lancet
دوره 366 9489 شماره
صفحات -
تاریخ انتشار 2005